rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer

Colorectal cancer is the third most incident cancer and cause of cancer-related death in the United States. MicroRNAs, a class of small non-coding RNAs, have been implicated in the pathogenesis and prognosis of colorectal cancer, although few studies have examined the relationship between germline mutation in the microRNAs with risk and prognosis. We therefore investigated the association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and colorectal cancer.A cohort consisting of 245 cases and 446 controls was genotyped for rs4919510. The frequency of the GG genotype was significantly higher in African Americans (15%) compared to Caucasians (3%) controls. There was no significant association between rs4919510 and colorectal cancer risk (African American: OR(GG vs. CC) 0.89 [95% CI, 0.41-1.80]) (Caucasian: OR(GG vs. CC) 1.76, ([95% CI, 0.48-6.39]). However, we did observe an association with survival. The GG genotype was associated with an increased risk of death in Caucasians (HR(GG vs. CC) 3.54 ([95% CI, 1.38-9.12]) and with a reduced risk of death in African Americans (HR(GG vs. CC) 0.36 ([95% CI 0.12-1.07).These results suggest that rs4910510 may be associated with colorectal cancer survival in a manner that is dependent on race

Comparing Notes: Recording and Criticism

This chapter charts the ways in which recording has changed the nature of music criticism. It both provides an overview of the history of recording and music criticism, from the advent of Edison’s Phonograph to the present day, and examines the issues arising from this new technology and the consequent transformation of critical thought and practice

Wider Still and Wider: British Music Criticism since the Second World War

This chapter provides the first historical examination of music criticism in Britain since the Second World War. In the process, it also challenges the simplistic prevailing view of this being a period of decline from a golden age in music criticism

Growth And Differentiation In Craspedacusta Sowerbii.

Ph.D.Biological SciencesZoologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/127231/2/6002549.pd

Lieutenant Andrew McClary, Quartermaster, Major John H. Buell, and John Mills, Adjutant General, Greenville, to the acting quartermaster

McClary, Buell and Mills request a ration of whiskey for the men and women in the companies under the command of Captain Daniel Bradley, Captain Edward Miller and Captain Andrews of the 2nd Sub Legion.Document signed by McClary, Buell and Mills, and countersigned on the reverse of paper by Elisha Thatcher, Quartermaster Sergeant, 2nd Sub Legion

Lieutenant Andrew McClary, Quartermaster, John H. Buell, Major, and John Mills, Adjutant General, to the assistant quartermaster

McClary, Buell and Mills request a ration of whiskey for the men and women in the companies under the command of Captain Bradley, Captain Miller and Captain Andrews of the 2nd Sub Legion.Document signed by McClary, Buell and Mills and countersigned on the reverse of paper by James Hefferman, Sergeant, 2nd Sub Legion

Lieutenant Andrew McClary, Quartermaster, Major John H. Buell, and John Mills, Adjutant General, Greenville

McClary, Buell and Mills request a ration of whiskey for the men and women in the companies under the command of Captain Daniel Bradley, Captain Edward Miller and Captain Andrews of the 2nd Sub Legion.Document signed by McClary, Buell and Mills, and countersigned on the reverse of paper by Elisha Thatcher, Quartermaster Sergeant, 2nd Sub Legion

Lieutenant Andrew McClary, Quartermaster, John H. Buell, and John Mills, Adjutant General, to the quartermaster

McClary, Buell and Mills request a ration of whiskey for the men and women in the companies under the command of Captain Daniel Bradley, Captain Edward Miller and Captain Andrews of the 2nd Sub Legion.Document signed by McClary, Buell and Mills and countersigned on the reverse of paper by Elisha Thatcher, Quartermaster Sergeant, 2nd Sub Legion